Mun na i ka ɲi ka sisi bɔ min be weele ko ‘Dan ka Anti-Finɛ min be yɛlɛma yɛlɛma’?

Smoke yiri bɔli yɔrɔ min be kɛnɛya, o be se ka kɛnɛya

Sisiɲɛ yiri bɔli (Cotinus coggia) be bɔ nin Mediterane - yiri nin furaburuw n’a yiriw la, o sababu fɛ, a be kɛ ni CO€ ye. Bi sɛgɛsɛgɛri y’a yira ko a ka biyɔaktiwi ɲagaminin ɲɔgɔn tɛ yen min b’a to a be kɛ fura barikaman ye ka funu ni oksidi stress furakɛ.

O la, a be se ka kɛ ko mɔgɔw be se ka ɲɔgɔn sɔrɔ.

Fizetini (Favonoid Antioxidant)

Anti- funu Action: A be NF{{0}ΔB tagamasiɲɛ sira minɛ, ka poro- funu (TNF- , IL-6) dɔgɔya fɔɔ ka se 50% ma.

Neuroprotective kɔlɔlɔw: A be joli -brain ka barikada don ka Nrf2 sira lawuli, ka glutathione hakɛ caya nerɔniw kɔnɔ ni 40% ye .

Kɔrɔya: A be seliliw sɛgɛsɛgɛ (a yira ko a bena dɔ bɔ saan- tagamasiɲɛw la minw be taga ni 35% ye bɛgɛnw ka kalanw na)

Gallotanninw (Polifenoli minw ka kan ka kɛ)

Mikrobiyɔmu yɛlɛmani: A be Akkermansia muciniphia nafaman (3-5 caya) yiriwali lawuli k’a sɔrɔ a be banakisɛw bali ka don mɔgɔ la .

Farikolo latanga: A be dɔ fara kolajɛni sɛgɛsɛgɛli kan ni fibroblaste baara lawulili ye (sɛgɛsɛgɛli kalanw b’a yira ko 25% be dɔgɔya) .

Metaboliki dɛmɛ .: insulini sɛgɛsɛgɛli AMPK ka baarakɛcogo fɛ (min be sukaro dɔgɔyali teliya 15-20%)

Tulu jɔnjɔnw (Terpen Complex)

Nafa minw be sɔrɔ ninakilifɛnw na: A be kɛ i n’a fɔ finchodilator (FEV1 ka ɲɛtaga ye 12-15% ye COPD banabagatɔw la)

Diinan: A be TRPV1 minɛbagaw yɛlɛma ka ɲɛsin dimimadafuraw ma (o be se ka suma ni lidocaine 5% ye dimi sɛgɛsɛgɛli la)

Banakisɛfagalanw ka baara: A be se ka kɛ ko a be se ka kɛ ko a be se ka kɛ sababu ye ka Staphyloccus sifaw (MIC 32-64 ug/mL) sɔrɔ.

Aplikasiyɔn saba minw sɛgɛsɛgɛra ka ɲɛ

1. Tasumako ɲɛnabɔli .

45% dɔgɔyali CRP hakɛ la (lɔgɔkun 12 sɛgɛsɛgɛli ni sɔgɔsɔgɔninjɛ banabagatɔw ye)

Ɲɛtagaba min kɛra IBD tagamasiɲɛw na (70% yɛlɛmani hakɛ fitinin-}modirate kolitis)

2. Farikoloɲɛnagwɛ ani Anti-Wari

A be dɔ fara farikolo ka yɛlɛmani kan ni 28% ye (kɔnomɛtiri sumaninw) .

A be UV- min be se ka kɛ 40% (vs. placebo) ye.

3. Metaboliki syndrome Dɛmɛ

A be HbA1c dɔgɔya ni 0,8-1,2% ye ka kɔn sukarodunbana ɲɛ .

A be 15% (CT scan sɛgɛsɛgɛnin sɛgɛsɛgɛ) dɔgɔya.

Baarakɛcogo minw be kɛ ka kɛɲɛ ni kɛnɛyako laɲinitaw ye .

Optimisation aption .

Ka ɲɛsin sisitɛmu kɔlɔlɔw ma: Aw k’a ta ni omega-3 ye min be ni omega-3 ye walisa ka biyɔdisibilite yiriwa .

Topikali baara: 2-5% hakɛ min be sɔrɔ serumw kɔnɔ fotoprotection .

Sinergisitiki faraɲɔgɔnkan .: A be baara kɛ koɲuman ni kurkumin ye (1:1 ratio)

Lakanali Profil

▲ A be se ka joli -} 10nan furaw di (INR kɔlɔsi ni warfarin ye)
▲ A be se ka kɛ ko farikolo yɔrɔ dɔw be se ka mɔgɔ farikolo yɔrɔ dɔw minɛ (a laɲinina)
▲ A ma baga min kɔlɔsira furakisɛ hakɛ la fɔɔ ka se 1g/kg ma bɛgɛnw ka kalanw na .

ɲumanya sɛgɛsɛgɛli

1 HPLC- ye fisitɛtini hakɛ lajɛ (min ka dɔgɔ 8%)
- Kongoya-} min be bɔ Mediterane maraw la .
1 Nɛgɛ girinmanw (ICP-MS ka sɛbɛn)

Mɔgɔ minw be baara kɛ n’u ye, olu ka rapɔɔriw

"Nne ka sɔgɔsɔgɔninjɛ dimi dɔgɔyara fɔɔ ka se ka biyɔlozi hakɛ dɔgɔya ni tilancɛ ye" - 54F, kalo 6 be baara kɛ .
"Kalo 3 tɛmɛnin kɔ, n ka farigoloɲɛɲinibaga ko n ka tile yɔrɔw tun be komi u ka dɔgɔ ni saan 10 ye" - 41M .

Daliluw

NF{{0}κB Adibition .(Tileben blot sɛgɛsɛgɛri)

72,3% ka p65 nukeleyɛri yɛlɛmani .

Gut Microbiyɔmu ka yɔrɔw(16S rRNA ka tugutugu ɲɔgɔn kɔ)

4,2-siɲɛw caya Faikalibaktɛri prausnitzi .

Mun na i ka ɲi ka sisi bɔ mobili kɔnɔ?
O yiri min ma bonya la a kan, o be nafa caaman di mɔgɔw ma minw be se ka yɛlɛma ka taga yɔrɔ wɛrɛw la, k’a ta ɲɔgɔn ma ka taga a bila farikolo yɛlɛmani dɛmɛ na, o bɛɛ be sɔrɔ lɔnnikow fɛ. A tɛ i n’a fɔ furakɛli minw be kɛ ni kelen ye, a ka fitompaki sifa caaman be baara kɛ sira caaman fɛ walisa ka farikolo ka bɛnbaliya lasegin.